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How Does Medication For ADHD Work? The most frequently prescribed medications that doctors prescribe to manage ADHD work by increasing levels of chemical substances in the brain called dopamine and norepinephrine. They are available in short-acting and extended-release formulations. It may take some time before you or your child find the right medication and dosage for them. In addition, medication lifestyle changes, lifestyle modifications can improve symptoms. Methylphenid

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