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Inflammatory paths including the high-mobility-group-box-1 necessary protein, receptor-for-advanced-glycation-end-products and toll-like-receptor-4 (HMGB1/RAGE/TLR4) and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome pathways are usually important people in this link. Activation of the pathways comes to an end by releasing various inflammatory mediators involved with CVD and depression pathophysiology. In the mind, thi