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02). PONV was more frequent in the younger group at 1 and 6h after surgery (P 0.005). Rescue antiemetics were required in 29 premenopausal and 13 postmenopausal women (P = 0.01). Hospital stay was shorter for the older patients (P = 0.01). Minor morbidity was observed in both groups (0.7% and 2.1%). There was no mortality. Early PONV and pain after LC were more frequent in premenopausal women, who also required more rescue analgesic and antiemetic medication. Early PONV and pain after LC were more frequent in premenopausal women, w