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Vitreous analysis showed numerous gram-negative bacilli and a positive culture of . The patient continued to be managed with frequent lubrications and punctual plugs in the fellow eye during the follow-up period. We describe the first case of endophthalmitis developing secondary to PNP-induced corneal melting and perforation. Anticipating unusual infectious sequelae in the setting of PNP might be warranted to actively detect and successfully manage dry eye disease before devastating complications develop. We describe the first case of e