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Even with careful autopsy, a proportion of sudden deaths, including 2 to 54%, remain unexplained and this broad range of values is probably due to the heterogeneity of autopsy protocols. Post-mortem diagnosis of cardiac amyloidosis nevertheless represents a challenge for forensic pathologists. Detailed morphologic research associated with the heart and a total histopathologic study tend to be mandatory. Immunohistochemistry is important for amyloid subclassifica