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The use of drugs as a therapy for traumatic ulcers may lead to drug resistance and other side effects. Shirota can affect the number of fibroblasts and blood vessels in wound healing. The aim of this study was to investigate the difference in the number of fibroblast cells and blood vessels after the topical and systemic administration of Shirota probiotics in Wistar rats with traumatic ulcer. Overall, 36 healthy male Wistar rats aged 2-3 months old and weighing 175-250 g in body weight were used as a sample. Traumatic ulcer was made on

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