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We envision that this strategy would lead to insights into SO2 concentration-dependent biological effects and cell signals.In this work, polyoxometalate-modified magnetic nanocomposite Fe3O4@PDA@POM was prepared by coating [Cu(HL)4]2[P2Mo5O23]2·8H2O (POM, L = 2-aminopyridine) on the surface of a preassembled polydopamine (PDA)-capped carboxyl-functionalized Fe3O4 magnetic microspheres. Our studies on Gram negative bacterium Escherichia coli (E. coli) indicated that owing to the collective effect between preassembled Fe3O4 and POM, the