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Six programs (Adult and Pediatric Kinetics, BestDose, DoseMeRx, InsightRx, MwPharm++, and PrecisePK) were evaluated. Among neonatal models, Frymoyer et al. and Capparelli et al. used the largest PK samples to generate their models, which were externally validated. Among the pediatric models, Le et al. employed the largest sample size, with multiple external validations. Of the Bayesian programs, DoseMeRx, InsightRx, and PrecisePK utilized clinically validated neonatal and pediatric models. To optimize vancomycin use in neon