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39% (21/103) in the NC group. With the increase of age, the incidence of POD in all age groups increased (P less then 0.05). Logistic regression analysis showed that after adjusting for SCD, Aβ42, Aβ40, P-tau, and T-tau, SCD (OR 2.32, CI 1.18-4.55, P = 0.01) and the increased CSF level of P-tau (OR 1.04, CI 1.01-1.06, P less then 0.001) were risk factors for POD, while the level of aβ42 (OR 0.99, CI 0.99-1.00, P less then 0.001) was a protective factor for POD. Conclusion SCD is one of the preoperative risk factors for POD. Clinical T
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