https://ifenprodilantagonist.c....om/orbital-top-syndr
Unfortunately, few investigations into the design compatibility of CRISPR components in AAV vectors occur. Using AAV-genome population sequencing (AAV-GPseq), we formerly found that self-complementary AAV vector designs with strong DNA secondary structures can cause a top degree of truncation occasions, affecting manufacturing and vector effectiveness. We hypothesized that the single-guide RNA (sgRNA) scaffold, which contains several cycle areas, may also compromise vector stability. We now have c
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