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001), while the mRNA levels of significantly decreased after 12 hours (P=0.003) and 24 hours (P=0.001). expression was increased in the HeLa cells after 6 and 12 hours (P0.001) whereas γ-H2AX levels significantly increased after 24 and 48 hours of treatment (P0.001). AWHE possesses growth inhibitory activity by altering the expression of cell death-associated genes. Using extracts from herbal plants may provide alternative strategies to be deployed in the fight against cancer. AWHE possesses growth inhibitory activity by altering