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OL in HFpEF and for the design of future clinical trials targeting symptom improvement in HFpEF. CLINICAL TRIAL REGISTRATION RELAX, NCT00763867; NEAT-HFpEF, NCT02053493; INDIE-HFpEF, NCT02742129. © 2020 European Society of Cardiology.Invited for the cover of this issue is the group of Cristiano Zuccaccia at the Università degli Studi di Perugia. The image depicts a relation of the nuances of chemical bonding to the diverse ways that animals "bind" to their natural surroundings. Read the full text of the article at 10.1002/chem.201905699
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