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DF3016A is a novel potent and discerning C5a receptor (C5aR) inhibitor that crosses the blood-brain buffer (Better Business Bureau) and may have pharmacological properties. We now have formerly demonstrated a protective effect of DF3016A on hurt main cortical neurons by oxygen-glucose deprivation-reoxygenation (OGD/R) model to mimic the neuroinflammatory process. Here, we investigated the molecular path and facets mixed up in neuroprotection previously reported. Our results show that DF3016A safeg