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The stimulation of this nerve triggers subcortical nuclei, including the locus coeruleus in addition to nucleus regarding the solitary tract , and from there, the activation propagates towards the cortex. Since tVNS is a novel stimulation strategy, this literature review outlines a short historic background of tVNS, before detailing underlying neurophysiological mechanisms of activity, stimulation parameters, cognitive results of tVNS on healthier humans, and