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Copyright © 2020 American Chemical Society.IL-33 happens to be deorphanized as a member of this IL-1 family members and has crucial roles as an alarmin and cytokine with powerful ability to drive kind 2 infection. This has resulted in an array of studies surrounding its role in chronic diseases with a sort 2 inflammatory element. Here, we review the roles of IL-33 in two chronic respiratory conditions, asthma and chronic obstructive pulmonary disease (COPD). We discuss the character