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However, the inflamed SAEC fails to adapt to the NM exposure due to an impaired nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated cytoprotective response. The findings reveal that susceptibility to pulmonary nanotoxicity is highly dependent on the interplay between NM properties and inflammation of the alveolar milieu. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.BACKGROUND Lung protective ventilation (LPV) has been applied to surgical adults with normal pulmonary function for optimizing mechanic ventilation and redu

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