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https://www.selleckchem.com/pr....oducts/telacebec-q20
Ex-9 also suppressed IBMX- and glucose-induced [cAMP] elevations. Depolarization with K triggered Ca -dependent [cAMP] elevation, an effect that was amplified by high glucose. Ex-9 inhibited both the Ca and glucose-metabolism-dependent actions on [cAMP] . The drug remained effective after minimizing paracrine signalling by dispersing the islets and it reduced basal [cAMP] in a cell-line heterologously expressing GLP1Rs, indicating that there is constitutive GLP1R signalling. The ex-9-induced reduction of [cAMP] in glucose-stimula

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