https://www.selleckchem.com/pr....oducts/sb-415286.htm
Alveolar epithelial cell (AEC) apoptosis arising from mitochondrial dysfunction and mitophagy defects are important in mediating idiopathic pulmonary fibrosis (IPF). Our group established a role for the mitochondrial (mt) DNA base excision repair enzyme, 8-oxoguanine-DNA glycosylase 1 (mtOGG1), in preventing oxidant-induced AEC mtDNA damage and apoptosis and showed that OGG1-deficient mice have increased lung fibrosis. Herein, we determined whether mice over-expressing mtOGG1 transgene (MtOgg1tg) are protected against lung fibrosis an
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