https://www.selleckchem.com/
Bone remodeling is affected by mechanical stimulation. Osteocytes are the primary mechanical load-sensing cells in the bone, and can regulate osteoblast and osteoclast activity, thus playing a key role in bone remodeling. Further, bone mass during exercise is also regulated by Leukemia inhibitory factor (LIF). This study aimed to investigate the role of LIF in the mechanical response of the bone, and , and to elucidate the mechanism by which osteocytes secrete LIF to regulate osteoblasts and osteoclasts. A tail-suspension (TS) mouse model was used in this s
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