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Studies in vitro and in vivo have proved that osteosarcoma-secreted exosomes from miR-195-3 p upregulated 143B osteosarcoma cells promote cell proliferation and invasion. Overall, the present study identified exosomal miRNAs with dysregulated expression in patients with osteosarcoma, and they may have potential as targets for the treatment of patients with osteosarcoma. © American Federation for Medical Research 2020. No commercial re-use. See rights and permissions. Published by BMJ.Extensive studies have shown that the sigma-1 receptor (σ
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