https://www.selleckchem.com/pr....oducts/bgj398-nvp-bg
Genome engineering provides a powerful tool to explore TGF-β/SMAD signaling by enabling the deletion and modification of critical components of the pathway. Over the past years, CRISPR-Cas9 technology has matured and can now be used to routinely generate knockout cell lines. Here, we describe a method to design and generate deletions of genes from the SMAD pathway in somatic human cell lines based on homologous recombination.Transforming growth factor-β (TGF-β) family members have pivotal functions in controlling breast cancer
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