https://www.selleckchem.com/pr....oducts/Telaprevir(VX
TDP-43 is a primary pathological hallmark protein of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, which may exist in the form of amyloid inclusions in the cells of patients. In addition to serving as a biomarker for these diseases, TDP-43 can also directly trigger neurodegeneration. We previously determined the amyloidogenic core region of TDP-43 (residues 311-36 and showed by solution NMR that this region includes two α-helices [(321-33 and (335-343)] in solution. We suggested that the helix-to-sh
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