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In early implementation of non-pharmaceutical interventions, an intensive lockdown has had a profound impact on the mitigation of a large-scale COVID-19 outbreak in Oman. The role of innate lymphoid cells (ILCs) in coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is unknown. Understanding the immune response in COVID-19 could contribute to unravel the pathogenesis and identification of treatment targets. Here, we describe the phenotypic landscape of circulating ILCs in COVID-19 pa