https://agerafenibinhibitor.co....m/?p=1766preview=tru
In our study, whether PNS could limit cyst necrosis factor (TNF)‑α‑induced senescence and apoptosis in chondrocytes and if they could delay cartilage degeneration in a surgery‑induced rat osteoarthritis (OA) model by controlling the phosphatidyl inositol 3 kinase (PI3K)‑protein kinase B (AKT)‑mammalian target of rapamycin (mTOR) signaling pathway was examined. A potential system fundamental these effects was additional elucidated. The present in vitro experiments indicated that PNS dramatically inhibited senescence and apoptosis
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