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Previous studies have identified and validated a risk-associated Active transcriptome phenotype frequently expressed into the cancer-adjacent and histologically normal epithelium, stroma, and adipose containing peritumor microenvironment of medically set up invasive breast cancers, conferring a 2.5- to 3-fold later risk of dying from recurrent cancer of the breast. Expression of this Active transcriptome phenotype have not however already been examined in normal breast tissue samples una