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Western blotting studies indicated that HaCaT cells which were pre-treated with PTE (100 μM) and then co-treated with H O (600 μM) for 12 h showed significantly increased levels of SOD (Cu/Zn), SOD (Mn), Bax, caspase-3, caspase-8, caspase-9, PARP, p53, p-p53, and p-H2A.X but decreased levels Bcl-2 and catalase. Results also showed that HaCaT cells pre-treated with PTE and then co-treated with H O had increased expression of SOD (Cu/Zn) and glutathione but decreased catalase. These observations suggest that PTE pre-treatment can enhance the
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