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RT-PCR demonstrated that the mRNA expressions of VEGF, NDRG2, IL-6, and STAT3 were remarkably higher in model group than those in control group (p less then 0.05). However, they decreased significantly in CLT-005 group (p less then 0.05). Model group exhibited remarkably higher protein expressions of NDRG2, IL-6, and STAT3 than control group (p less then 0.05). However, CLT-005 group had decreased protein expressions of these molecules (p less then 0.05), which were close to those in control group. CONCLUSIONS The activation of NDRG2/IL-
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