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Right here we report that lipid-raft microdomains are crucial aspects of phagolysosomal membranes of macrophages and depend on flotillins. Hereditary removal of flotillins shows that the construction of both significant defense buildings vATPase and NADPH oxidase requires membrane microdomains. Furthermore, we explain a virulence apparatus causing dysregulation of membrane microdomains by melanized wild-type conidia of this important human-pathogenic fungi Aspergillus fumigatus resulti
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