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GO and KEGG analyses were used to identify the most likely purpose of the genes included. Also, we evaluated the useful need for solitary nucleotide polymorphisms using RegulomeDB and GTEx. Seven eligible researches concerning 29 genes and 89 SNPs were examined in this review. We found that the polymorphisms in gene NOS2, NOG, BMP4, CYR61, IL1β and FGFR1 apparently predisposed patients to fracture non-union, while the polymorphisms in gene MMP13, BMP6 and FAM5C seemed to provide defense
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