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The final pathology report revealed absence of residual disease (ie, pathological complete response, ypT0ypN. During follow-up, the only relevant and permanent immune-mediated adverse event was hypothyroidism secondary to an autoimmune thyroiditis. It appeared 2 mo after radical cystectomy and it was managed successfully with hormonal replacement therapy. Two years after treatment, the patient is asymptomatic and free from disease recurrence. PATIENT SUMMARY Increasing evidence suggests that frontline neoadjuvant immunotherapy may be
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