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93%, 19.94%, and 10.66%, respectively, and the difference between the high-dose group and the model group was statistically significant(P0.05). FFE decreased the viral load in brains of HSE mice. The levels of TNF-α, IL-1β, and IFN-α in ACV group and high-dose and medium-dose FFE groups were lower than those in the model group(P0.01,P0.05), and NO content in the three FFE groups was lower than that in the model group(P0.01). In conclusion, FFE can improve the survival rate of HSE mice, reduce the load of herpes simplex v
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