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Here we have utilized microarray analysis to search for differentially expressed genes in isolated patient derived epithelial and fibroblast cells. The transcription factor NFE2L3 has been shown to be upregulated in fibroblast cells consistent with increasing evidence that fibroblasts play a key role in tissue specific inflammation within the paranasal sinuses. Pregnancy as an immunosuppressive condition and with the associated tendency for mucosal oedema can predispose women to acute rhinosinusitis. Our hypothesis was that pregnancy enh
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