https://www.selleckchem.com/pr....oducts/ccs-1477-cbp-
potent in the aorta compared to 5-HT but less efficacious, serving as partial agonists. By contrast, these same three agonists caused no contraction in the vena cava isolated from the same rats up to a 10 μM agonist concentration. Antagonism of the 5-HT7 receptor by SB269970 did not increase either the potency or efficacy of TCB-2 or NBOH. These data support that the 5-HT7 receptor itself needs to be stimulated to reduce contraction and that there is little constitutive activity of the 5-HT7 receptor in the isolated abdominal
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