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The assembled information could afford functional clues to investigators, conducive to further experimental pursuits. © Sleep Research Society 2020. Published by Oxford University Press [on behalf of the Sleep Research Society].Plasmin (Pm) is a serine protease that can dissolve fibrin clots. Several possible functions of Pm in blood other than fibrinolysis have been proposed. To explore the effects of Pm on primary hemostasis, we evaluated the cleavage of von Willebrand factor multimers (VWFMs) in human plasma by streptokinase (SK)-act