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g., societal versus personal), or the origin of the values that motivate research participation. The HIV treatment literature reveals the critical role of clinical interactions in fostering altruism. There remains a dearth of in-depth knowledge regarding reasons surrounding research participation and the types of altruism displayed in HIV cure-related clinical research. Lessons learned from various research fields can guide questions which will inform the assessment of altruism in future HIV cure-related research. Lessons learned from