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Stabilizing the DNA and RNA structures known as G-quadruplexes (G4s) using specific ligands is a strategy that has been proposed to fight cancer. However, although G-quadruplexligand (G4L) interactions have often been investigated, whether or not ligands are able to disrupt G-quadruplexprotein (G4P) interactions remains poorly studied. In this study, using native mass spectrometry, we have investigated ternary G4LP complexes formed by G4s, some of the highest affinity ligands, and the binding domain of the RHAU helicase. Our results sugg
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