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These findings suggest the clinical relevance of KMO in CRC tumorigenesis and aggressiveness. Literature is non-conclusive regarding selection of beam configurations in radiotherapy for mediastinal lymphoma (ML) radiotherapy, and published studies are based on manual planning with its inherent limitations. In this study, coplanar and non-coplanar beam configurations were systematically compared, using a large number of automatically generated plans. An autoplanning workflow, including beam configuration optimization, was configured for

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