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Five manuscripts, including one preprint, examining six cohorts had been included four used painDETECT or modified painDETECT, one the Self-Report Leeds Assessment of Neuropathic signs a sensitisation, predict customers at greater risk of pain following leg replacement.The Krebs cycle-derived metabolite itaconate is very upregulated in inflammatory macrophages and exerts immunomodulatory effects through cysteine modifications on target proteins. The NLRP3 inflammasome, which cleaves IL-1β, IL-18, and ga
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