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Nevertheless, rapid lung buildup after intraveous injection and notably reduced transfection effectiveness (TE) in serum significantly hamper its application. In this research, we attempt to research the fate of Mannose-PEG1000-lipoplex (MP1000-LPX) in vivo, a previous reported mRNA vaccine, and possible process with it. MP1000-CLs and differing type of MP1000-LPX were created by previous strategy and characterized by dynamic light-scattering (DLS). Organ distribution and Luc-mRNA expression of DiD loaded

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