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Knee osteoarthritis (KOA) is currently indicated to be characterized by destruction of articular cartilage. The destruction can be described as an imbalance between synthesis and degradation of extracellular matrix (ECM) components. It is accompanied with changes of pro-inflammatory cytokines and degradation enzymes dominated by matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS). Recent studies have revealed that microRNAs (miRNAs) are associated with synthesis and degradation of ext
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