https://www.selleckchem.com/pr....oducts/aminoguanidin
Autism spectrum disorder (ASD) encompasses a group of neurodevelopmental conditions that remain poorly understood due to their genetic complexity. CHD8 is a risk allele strongly associated with ASD, and heterozygous Chd8 loss-of-function mice have been reported to exhibit macrocephaly in early postnatal stages. In this work, we sought to identify measurable brain alterations in early embryonic development. We performed light-sheet fluorescence microscopy imaging of N-cadherin stained and optically cleared Chd8 and w
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