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Such performances significantly outperform control catalysts and analogues. Even more importantly, the original concept of coordinated regulation presented in this work can broaden our horizons in the design of new and highly efficient catalysts for neutral water splitting.Arterial stiffness is a complex process affecting the aortic tree that significantly contributes to cardiovascular diseases (systolic hypertension, coronary artery disease, heart failure or stroke). This process involves a large extracellular matrix remodeling mainly

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