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Right here, we identify alkaline phosphatase placental-like 2 (ALPPL2) as a prominent naive-specific area marker by organized proteomic and transcriptomic analyses. Furthermore, we show that ALPPL2 is vital for both the establishment and upkeep of naive pluripotency. More over, we show that ALPPL2 can communicate with the RNA-binding protein IGF2BP1 to stabilize the mRNA levels of the naive pluripotency transcription facets TFCP2L1 and STAT3 to modify naive pluripotency. Overall, our study i
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