https://www.selleckchem.com/ph....armacological_epigen
Background and purpose mPGES-1 catalyzes the production of prostaglandin E2 (PGE2 ), the most abundant prostanoid related to inflammation and pain in arthritis. mPGES-1 is suggested to be a safer and more selective drug target in inflammatory conditions compared to the COX enzymes targeted by NSAIDs. In the present study, we investigated the effects of the selective mPGES-1 inhibitor MF63 on gene expression in primary human chondrocytes from patients with osteoarthritis (OA). Experimental approach Chondrocytes were isolated f
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