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Among the host restriction factors against HIV, SERINC5 has been described in vitro, but the mRNA level of SERINC5 in vivo has been little studied. We compare SERINC5 expression in subjects with HIV-1 (highly active antiretroviral treatment (HAART) and HAART-naïve) with and without suppression of viral load. A cross-sectional study was performed with 107 individuals distributed as follows 24 with HAART-naïve and detectable viral load ( 50 copies/mL), 13 with HAART and detectable viral load ( 50 copies/mL), 50 with HAART and unde