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In recent years, metabolomic analyses have been increasingly performed in studies with an epidemiological design. Since 2012, the National Cancer Institute has recognized the importance of supporting these efforts by strategically building resources and infrastructure to move this area forward. This review outlines those efforts, including building infrastructure, leveraging existing resources, establishing the COnsortium of METabolomics Studies (COMETS), and improving rigor and reproducibility.Quantitative modeling of the subcutaneous ab