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To evaluate through histological and histomorphometric analysis of human biopsies the guided bone regeneration (GBR) potential of allograft, xenograft, and alloplastic materials in combination with resorbable membranes in sockets following extraction. This randomized controlled clinical trial comprised three experimental groups and one negative control group (n=8). Thirty-two patients were randomized and pos-extraction sockets received either an allograft (human cancellous bone, freeze dried, DIZG, Berlin), xenograft (BioOss; Geistlich