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04 95%CI 1.86-2.23; frailty OR 2.49 95%CI 1.99-3.13), length of stay, costs, and complications. In multivariate, prefrailty and frailty were associated with higher mortality (prefrailty aOR 2.02 95%CI 1.84-2.21; frailty aOR 2.54 95%CI 2.02-3.19). This study shows the presence of frailty (and prefrailty) is an independent risk factor of adverse postoperative outcomes in patients undergoing cholecystectomy. This study shows the presence of frailty (and prefrailty) is an independent risk factor of adverse postoperative outcomes in patients