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of the microalga Scenedesmus rubescens and niacinamide (Vitamin B3) have the potential to protect against blue light induced hyperpigmentation.Rationale Fentanyl and its analogues play an important role in hospital and clinic as anesthetic. However, illicitly manufactured fentanyl as well as the new psychoactive substances (NPS) account for 30% of all deaths in the United States. Since fentanyl derivatives and NPS are designed to produce similar effects, their related substances are similar or even have same active groups. A comprehensiv