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Finally, we use estimates of the effective rate of recombination to calculate the rate of sex that occurs in natural populations, estimating a sexual cycle roughly every 840 generations. We argue that the relatively infrequent rate of sex and large effective population size creates a population genetic environment that increases the influence of selection on linked sites across the genome. © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.AIMS The dysregulation and essential role of WNTs
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